Expression of Long Noncoding RNA, HOTAIR, and MicroRNA-205 and Their Relation to Transforming Growth Factor β1 in Patients with Alopecia Areata

This study investigated the expression levels of long noncoding RNA HOTAIR and microRNA-205, as well as their relationship with transforming growth factor β1 (TGF-β1) in patients with alopecia areata (AA). The case-control study included 50 AA patients and 50 healthy controls. Results showed that lncRNA HOTAIR was significantly downregulated, while miRNA-205 and TGF-β1 were significantly upregulated in AA patients. These findings suggested that the altered expression of these molecules could play a role in the pathogenesis of AA and might serve as potential therapeutic targets for treatment.