Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials?

This review analyzes 12 clinical studies on the use of extracellular vesicles (EVs), including exosomes, for treating skin aging, acne scars, alopecia, and wound healing. The findings indicate that EVs and exosomes hold promise in regenerative skin therapies, offering innovative and non-invasive treatment options. Notable studies include one with 30 participants showing increased hair density in alopecia treatment and another with 25 participants demonstrating improved acne scar appearance with exosome and laser therapy. Despite these promising results, challenges such as the standardization of EV production, lack of large-scale randomized studies, and regulatory issues remain. The review emphasizes the need for more comprehensive clinical trials to validate the long-term safety and efficacy of EV-based therapies in dermatology.