Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials?

The analysis of 12 clinical studies on extracellular vesicles (EVs), including exosomes, reveals their potential in regenerative skin therapies for conditions like skin aging, acne scars, alopecia, and wound healing. These therapies offer innovative, non-invasive approaches, but face challenges such as production standardization and a lack of large-scale randomized studies. The review also evaluates these studies against the MISEV criteria, providing a comprehensive overview of EV applications in skin therapy and highlighting the need for further research.