Health Utility of Facial Angiofibroma Associated with Tuberous Sclerosis Complex

The study assessed the health utility of facial angiofibroma (FA) in Tuberous Sclerosis Complex by evaluating the quality of life impact from a general population perspective. Involving 100 participants, the study used visual analogue scale, time trade-off, and standard gamble methods to determine health state utilities for almost-clear and moderate FA. Results showed adjusted mean utilities of 0.88, 0.95, and 0.94 for almost-clear FA, and 0.68, 0.88, and 0.91 for moderate FA, respectively. Participants indicated a willingness to sacrifice 12% of their remaining life or accept a 9% risk of immediate death for curative treatment of moderate FA. The study concluded that moderate FA significantly reduces quality of life compared to almost-clear FA, emphasizing the benefits of treatment.