Facial pore refining by targeting dermal and epidermal functions: Assessment across age and gender

The study investigates the effectiveness of a composition containing mannose-6-phosphate (Active Complex) in refining facial pores by targeting dermal and epidermal functions. Enlarged pores are linked to collagen density loss and abnormal keratinocyte differentiation. Active Complex was shown to upregulate collagen synthesis and downregulate matrix metalloprotease, enhancing dermal protection. It also modulated keratinocyte differentiation and cell renewal. Clinical trials involving Caucasian women and Asian men demonstrated significant pore reduction, with a -24% decrease in total skin pore area in women after 56 days and a -30.2% decrease in men after 7 days. The findings highlight the potential of targeting dermal and epidermal changes to address pore enlargement.