The Hair Loss Encyclopedia

Facial Skin Aging: An Integrative Analysis of Genetics, Epigenetics, and Lifestyle Factors

December 2025 in “ GeroScience ”

Rezvan Noroozi, Aleksandra Pisarek-Pacek, B. Wysocka, Kamila Migacz-Gruszka, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Dagmara Lisman, Julia Zacharczuk, Joanna Rudnicka, Aleksandra Iljin, Kathryn C. Fitzgerald, Małgorzata Magdalena Michalczyk, Piotr Kaczka, Michał Krzysztofik, Maciej Kostrzewa, Aneta Sitek, Magdalena Spólnicka, Andrzej Ossowski, Wojciech Branicki, Ewelina Pośpiech

This study investigates the impact of genetics, epigenetics, and lifestyle on facial skin aging, analyzing over 700 Polish individuals. It identifies novel genes, such as EDAR and NRG1, linked to facial wrinkles and highlights the role of environmental stressors. Epigenetic aging correlates with facial wrinkle area and perceived age, with GrimAge and FitAge clocks showing strong associations. Genome-wide SNP analysis reveals associations with wrinkle area and perceived age, suggesting stress response and adiposity involvement. The study demonstrates that combining methylation and SNP data can predict variations in skin phenotypes, explaining 59.0% of wrinkle area and 26.2% of perceived age, offering valuable insights for dermatology and anti-aging strategies.

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Research cited in this study

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research Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging

31 citations , December 2023 in “GeroScience”

research Recent Advances in Forensic DNA Phenotyping of Appearance, Ancestry, and Age

89 citations , April 2023 in “Forensic Science International Genetics”

Forensic DNA Phenotyping can now better predict appearance, ancestry, and age from DNA, but more research is needed for precise police use.

The Link Between Obesity and the Skin

research The Link Between Obesity and the Skin

12 citations , March 2022 in “Frontiers in Nutrition”

Obesity is linked to various skin conditions and issues, and losing weight can improve these conditions.

research Exploring the Possibility of Predicting Human Head Hair Greying from DNA Using Whole-Exome and Targeted NGS Data

37 citations , August 2020 in “BMC Genomics”

Hair greying is mainly influenced by age, with genetics playing a smaller role.

Genome-Wide Association Study in Japanese Females Identifies Fifteen Novel Skin-Related Trait Associations

research Genome-Wide Association Study in Japanese Females Identifies Fifteen Novel Skin-Related Trait Associations

58 citations , June 2018 in “Scientific reports”

Researchers found 15 new genetic links to skin traits in Japanese women.

A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features

research A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features

196 citations , March 2016 in “Nature Communications”

Genetic factors influence hair traits like shape, color, and greying in Latin Americans.

Why Some Women Look Young for Their Age

research Why Some Women Look Young for Their Age

175 citations , November 2009 in “PLOS ONE”

Women look young for their age due to larger lips, less sun damage, and genes that prevent gray hair and wrinkles.

Obesity and the Skin: Skin Physiology and Skin Manifestations of Obesity

research Obesity and the Skin: Skin Physiology and Skin Manifestations of Obesity

405 citations , May 2007 in “Journal of The American Academy of Dermatology”

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.