Diversity of Fibroblasts and Their Roles in Wound Healing

September 2022 in “ Cold Spring Harbor Perspectives in Biology ”

Dongsheng Jiang, Ruiji Guo, Hans‐Günther Machens, Yuval Rinkevich

TLDR Different fibroblast types play key roles in wound healing and could lead to better treatments.

The document reviewed the diversity of fibroblasts and their crucial roles in wound healing, highlighting that fibroblasts are not a uniform group but consist of various subtypes with different embryonic origins and anatomical locations. These subtypes perform fundamental physiological functions that influence wound repair and healing outcomes. Understanding the heterogeneity of fibroblast populations was suggested to potentially lead to new therapies aimed at improving wound healing and reducing excessive scarring.

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