Strength And Tenderness: Fibronectin Joins Hair Follicle Stem Cell Niche

The study by Estrach et al. (2025) reveals that fibronectin (FN) secreted by hair follicle stem cells (HF-SCs) is crucial for hair follicle regeneration. HF-SC-derived FN interacts with integrin receptors to activate the YAP/TAZ signaling pathway, vital for HF-SC function. Conditional deletion of FN in HF-SCs disrupts their localization and function, indicating their role in creating a regenerative niche. The research also examines mechanosensing pathways, such as the PIEZO1 channel, in maintaining HF-SC health and suggests FN's therapeutic potential in rejuvenating aged skin with compromised extracellular matrix (ECM). These insights advance our understanding of stem cell behavior in skin diseases and aging.