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research Author response: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

September 2021

Reducing PIEZO1 speeds up wound healing.

research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

23 citations , October 2021 in “Cell Stem Cell”

Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.

research Strength and Tenderness: Fibronectin Joins Hair Follicle Stem Cell Niche

August 2025 in “Journal of Investigative Dermatology”

Fibronectin is essential for hair follicle regeneration and may help rejuvenate aged skin.

research 0932 Spatiotemporal gradient of mesenchymal stiffness controls sweat gland morphogenesis

July 2026 in “Journal of Investigative Dermatology”

Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.

research Editors’ Picks

April 2022 in “Journal of Investigative Dermatology”

Hair shaft miniaturization leads to hair follicle stem cell loss, suggesting Piezo1 as a potential treatment target.

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community GT20029 Will Replace Finasteride For Hair Loss

in Research/Science 57 upvotes 2 months ago

GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.

community What are your unpopular opinions on hair loss and its treatments?

in Chat 57 upvotes 1 year ago

Hair loss treatments like finasteride, minoxidil, and hair transplants are more accessible and effective now. Concerns about side effects and skepticism about new treatments like hair cloning and GT20029 remain.

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