Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial

    November 2025 in “ Journal of Multidisciplinary Healthcare ”
    Tao Zhu, Jin‐Zhen Li, Shiyue Sun, Yu-Fang Ji, Laixi Ji
    TLDR Combining fire needle therapy with doxycycline improves severe acne more than doxycycline alone.
    A randomized controlled trial conducted over 8 weeks demonstrated that combining fire needle therapy with doxycycline hydrochloride (DHT) significantly improved lesion severity, scar symptoms, quality of life, and serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.
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