Low-Molecular-Weight Fish Collagen Peptide Enhances Hair Regrowth via Activation of Proliferative Signaling and Suppression of Inhibitory Pathways

The study examined the effects of low-molecular-weight fish collagen peptide (SH-GT) on hair regrowth in a mouse model, involving 9 mice per group. SH-GT was administered orally at doses of 100, 300, and 600 mg/kg for 28 days, resulting in significant hair regrowth, increased dermal thickness, and higher hair follicle density. SH-GT activated proliferative signaling pathways, including Wnt/β-catenin and PI3K/Akt/mTOR, while suppressing inhibitory pathways like BMP/Smad. It also increased the expression of growth factors such as IGF-1, HGF, VEGF, EGF, and FGF7, suggesting SH-GT as a potential functional ingredient for promoting hair growth. Further research, including human trials, is recommended.