Fish Acellular Dermal Matrix Promotes Repair of Full-Thickness Skin Defects in Mice and Bama Pigs

This study developed an acellular dermal matrix from tilapia skin to evaluate its effectiveness in skin wound repair. The matrix showed low immunogenicity, preserved extracellular matrix architecture, and retained bioactive components. It significantly promoted cell activities in vitro and accelerated wound closure in vivo in Balb/c mice and Bama pigs, outperforming a commercial porcine-derived matrix. The matrix enhanced collagen deposition and vascularization, modulated biological pathways, and demonstrated excellent biocompatibility and therapeutic efficacy, suggesting its potential as a safe, economical, and sustainable bioscaffold for clinical skin repair. The use of a large animal model and transcriptomic analysis provided valuable insights into its translational relevance and mechanistic interactions.