TLDR Leptin may play a role in hair growth and hair follicle health.
The study revealed that human follicular papilla cells (FPC) from the scalp produced leptin, a hormone typically associated with adipose tissue, and expressed its functional receptor, suggesting a potential role for leptin in hair biology. The research involved 12 FPC lines and demonstrated leptin protein and mRNA presence in the hair follicle's lower portion. Various cytokines and growth factors were found to downregulate leptin production, indicating an autocrine function of leptin in hair biology. The findings suggested that leptin might influence hair growth and contribute to the immunoprivileged status of hair follicles, highlighting the need for further investigation into leptin's role in hair growth and biology.
100 citations
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November 1996 in “Molecular Medicine Today”
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