Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells

    February 2016 in “ Science ”
    Li Wang, Julie A. Siegenthaler, Robin D. Dowell, Rui Yi
    TLDR Foxc1 helps keep hair follicle stem cells inactive, preventing hair loss.
    The study revealed that the Foxc1 transcription factor played a crucial role in maintaining quiescence in hair follicle stem cells (SCs). When activated, these SCs induced Foxc1, which promoted Nfatc1 and BMP signaling to reinforce quiescence. Deleting Foxc1 in activated SCs led to a failure to reestablish quiescence and caused premature activation, while its deletion in the SC niche resulted in hair loss without affecting quiescence. Additionally, the study by Matsumura et al. identified type XVII collagen (COL17A1) as essential for preventing hair thinning during aging, as its depletion led to cell differentiation and hair follicle shrinkage. These findings highlighted the dynamic mechanisms by which hair follicle SCs maintained quiescence and cell identity.
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