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GlossaryFOXC1

gene encoding a transcription factor crucial for tissue development

FOXC1, or Forkhead Box C1, is a gene that encodes a transcription factor involved in the regulation of gene expression. This protein plays a crucial role in the development of various tissues, including the eyes, heart, and kidneys. Mutations in the FOXC1 gene can lead to developmental disorders such as Axenfeld-Rieger syndrome, which can affect the eyes and other parts of the body.

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research Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

142 citations , February 2016 in “Science”

Foxc1 helps keep hair follicle stem cells inactive, preventing hair loss.

Transcription Factor FOXC1 Positively Regulates SFRP1 Expression in Androgenetic Alopecia

research Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia

May 2021 in “Experimental Cell Research”

FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.

Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

research Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis

95 citations , July 2010 in “Genes & development”

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

research FOXE1, A New Transcriptional Target of GLI2 Is Expressed in Human Epidermis and Basal Cell Carcinoma

92 citations , May 2004 in “Journal of Investigative Dermatology”

FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

69 citations , January 2013 in “Frontiers in Immunology”

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

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