Freeze-Drying Tumor Tissues Derived Bio-Patches With Hair Melanin Nanoparticles Integration for Wound Healing

The study introduces a novel bio-patch for wound healing, derived from decellularized freeze-dried colon tumor tissues integrated with hair melanin nanoparticles (HNPs). These HNPs, sourced from human black hair, provide the patches with reactive oxygen species scavenging and photothermal-responsive antibacterial properties. The decellularization and freeze-drying processes preserve essential extracellular matrix nutrients, enhancing cell growth, migration, and angiogenesis. The dFCT-HNPs-GelMA bio-patches significantly improve wound healing in vivo by reducing oxidative stress, suppressing inflammation, and promoting angiogenesis, making them a promising solution for managing difficult-to-heal wounds.