From local to systemic: endoscopic findings reshape the diagnostic paradigm of satoyoshi syndrome – a case report

This case report describes a 50-year-old woman diagnosed with Satoyoshi syndrome (SS) through distinctive endoscopic findings, including severe atrophic gastritis with cystic polyps and duodenal villous atrophy. These findings, along with a low-grade gastric foveolar-type adenoma and a 22q11.21 microdeletion, suggest a genetic susceptibility to autoimmune diseases. The patient also exhibited symptoms of systemic lupus erythematosus (SLE) and had a history of generalized alopecia, muscle spasms, and other systemic symptoms. The report emphasizes the importance of endoscopic evaluation in diagnosing complex conditions like SS and highlights the need for future targeted therapies, as current treatments showed limited improvement.