Frontal Fibrosing Alopecia and Genital Lichen Sclerosus: Single-Center Experience

June 2020 in “ Journal of Cosmetic Dermatology ”

Sara Grassi, Giulia Tadiotto Cicogna, Francesca Magri, Maria Caterina Fortuna, Gemma Caro, Angelina Pernazza, G. Soda, Emanuele Miraglia, Sandra Giustini, Marta Carlesimo, Alfredo Rossi

frontal fibrosing alopecia lichen sclerosus lichen planus autoimmune process

TLDR Frontal fibrosing alopecia may be linked to genital Lichen sclerosus through an autoimmune process.

This study aimed to enhance the understanding of Frontal fibrosing alopecia (FFA) by examining its epidemiology, clinical features, and comorbidities in a retrospective analysis of 119 Caucasian patients (111 female, 8 male) from 2003 to 2019. The study found that 16% of patients had cutaneous, mucosal, or nail localization of Lichen planus (LP), and 10.61% had concomitant genital Lichen sclerosus (LS), with 4.38% presenting both LS and LP alongside FFA. The findings suggested a potential autoimmune process linking LS and FFA, highlighting the need for further research to understand this association.

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research Frontal Fibrosing Alopecia: Demographic and Clinical Characteristics of 490 Cases

53 citations , June 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Frontal fibrosing alopecia mainly affects postmenopausal women and may be linked to thyroid hormones.

research Medical Therapy for Frontal Fibrosing Alopecia: A Review and Clinical Approach

37 citations , April 2019 in “Journal of The American Academy of Dermatology”

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

research Genome-Wide Association Study in Frontal Fibrosing Alopecia Identifies Four Susceptibility Loci Including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

61 citations , January 2019 in “American Journal of Clinical Dermatology”

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

research Frontal Fibrosing Alopecia: A Case Series of 65 Patients Seen in a Single Italian Centre

23 citations , November 2018 in “Journal of the European Academy of Dermatology and Venereology”

The study concluded that severity of Frontal fibrosing alopecia is not linked to how long someone has it, can start before menopause, and eyebrow loss may be an early sign.

research Frontal Fibrosing Alopecia Among Men: A Clinicopathologic Study of 7 Cases

41 citations , July 2017 in “Journal of The American Academy of Dermatology”

Men with Frontal fibrosing alopecia typically lose hair on the front scalp and sometimes on sideburns and upper lip, with treatments showing varied success.

research Frontal Fibrosing Alopecia in Men: Presentations in 12 Cases and a Review of the Literature

8 citations , October 2016 in “Actas Dermo-Sifiliográficas”

FFA in men, often mistaken for other hair loss types, may be more common than thought and needs larger studies for confirmation.

research Frontal Fibrosing Alopecia in Men: Presentation of 12 Cases and Literature Review

26 citations , August 2016 in “Actas Dermo-Sifiliográficas”

Frontal Fibrosing Alopecia in men is often missed and can come with symptoms like facial bumps and hair loss on eyebrows and limbs.

research Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis

68 citations , May 2016 in “Experimental dermatology”

FFA's causes may include environmental triggers and genetic factors.

research Case Series of Familial Frontal Fibrosing Alopecia and a Review of the Literature

33 citations , January 2015 in “Journal of Cosmetic Dermatology”

Familial frontal fibrosing alopecia affects premenopausal women too, and early diagnosis is important, but no proven medication exists yet.

research Trichoscopic Features of Frontal Fibrosing Alopecia: Results in 249 Patients

46 citations , January 2015 in “Journal of The American Academy of Dermatology”

Trichoscopy helps diagnose and assess the severity of Frontal Fibrosing Alopecia.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

5 citations , March 2014 in “Journal of The American Academy of Dermatology”

The study suggests hormonal factors may play a role in Frontal Fibrosing Alopecia and that treatments like oral antiandrogens and steroids could be beneficial.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

339 citations , February 2014 in “Journal of The American Academy of Dermatology”

Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.

research Frontal Fibrosing Alopecia: A Review of 60 Cases

166 citations , April 2012 in “Journal of The American Academy of Dermatology”

Mostly postmenopausal Caucasian women get Frontal Fibrosing Alopecia, which often includes eyebrow loss and has limited treatment success.

research Postmenopausal Frontal Fibrosing Alopecia

57 citations , January 2003 in “Clinical and experimental dermatology”

Postmenopausal frontal fibrosing alopecia is a type of hair loss in postmenopausal women that may stop on its own but has no effective treatment.

research Postmenopausal Frontal Fibrosing Alopecia: Scarring Alopecia in a Pattern Distribution

332 citations , June 1994 in “Archives of Dermatology”

Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.

research Postmenopausal Frontal Fibrosing Alopecia

325 citations , June 1994 in “Archives of Dermatology”

Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.