Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition

    January 2025 in “ Discovery Medicine ”
    Ben Wang, Jie Dong, Fang Liu
    The study investigates the protective effects of fruit acids, specifically glycolic acid, on UV-induced skin photoaging in rats. Results show that fruit acid treatment reduces oxidative stress and inflammatory responses, enhances collagen recovery, and improves skin structure by decreasing epidermal keratinization and increasing dermal thickness. The treatment also increases antioxidant enzyme activities (SOD, CAT, GSH-Px) and collagen levels while reducing inflammatory markers (MDA, IL-6, IL-1β, IFN-γ, TNF-α). The underlying mechanism involves the inhibition of the PI3K/Akt and NF-κB signaling pathways, suggesting fruit acids as a potential therapeutic for skin photoaging.
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