Giant Keratoacanthoma Mimicking Squamous Cell Carcinoma in a Patient with Chronic Myeloid Leukemia

This article discusses a case of a 57-year-old man with chronic myeloid leukemia who developed a giant keratoacanthoma (GKA), a rare tumor variant that exceeds 20 mm in size. GKA is characterized by rapid growth and can be mistaken for squamous cell carcinoma (SCC), necessitating careful differential diagnosis. In this case, the tumor was a large exophytic mass located in the interscapular area, initially suspected to be SCC. The lesion was surgically excised with a margin of normal tissue, and histopathological evaluation confirmed the diagnosis. The study highlights the diagnostic challenges posed by GKA due to its atypical presentation and rarity, emphasizing surgical excision as the preferred treatment.