Preparation and Characterization of Ginger Peel Polysaccharide–Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity

The study explored the preparation and characterization of ginger peel polysaccharide–Zn (II) complexes, which showed enhanced anti-inflammatory activity compared to unmodified ginger peel polysaccharides. These complexes, primarily composed of glucose and galactose with a zinc content of 21.17 mg/g, were tested in a zebrafish model. They effectively reduced inflammation by modulating cytokine expression, decreasing pro-inflammatory markers (IL-1β, IL-6, IL-8, IL-12, and TNF-α) and increasing the anti-inflammatory cytokine IL-10. The Zn (II) modification improved the anti-inflammatory effects, suggesting potential applications for treating chronic inflammation-related diseases.