research Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.
TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.
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research TNF superfamily in skin appendage development
TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.
research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB
Hinokitiol may help treat hair loss by reducing inflammation and promoting hair growth.
research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.
research TNF‐inhibitor associated psoriatic alopecia: Diagnostic utility of sebaceous lobule atrophy
Shrinking of oil glands in the skin is a key sign of hair loss linked to TNF inhibitor drugs and may improve if the treatment is stopped.
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5 / 14 resultscommunity Dutasteride actually has different half lives depending on dose
Dutasteride's half-life varies with dosage, and lower doses can be effective with fewer side effects compared to finasteride. Some users report different side effects with dutasteride and finasteride, and extreme dosages of dutasteride are unnecessary and potentially harmful.
community Why hasn’t anyone made a "DHT sponge" biologic yet???
The conversation discusses the potential for developing a biologic "DHT sponge" to neutralize DHT in the bloodstream as a treatment for hair loss, suggesting it could be more targeted and have fewer side effects than current treatments like finasteride and dutasteride. Concerns include the complexity, cost, and potential side effects of such a treatment, as well as skepticism about its feasibility and market interest.
community The MPB itch aka DHT itch is very real.
Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.
community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas
Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.
community Finasteride does deplete important nuero-active steroids
Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.
Clinics
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Hair Loss TreatmentsTANVI Laser Cosmetic & Plastic Surgery- UNIT OF TANVI HOSPITALShivamogga, Karnataka · IN - 23
Hair TransplantHair Loss TreatmentsSMPHair SystemsDenova Aesthetic ClinicRawalpindi · PK - 30Hair SystemsdeNovo Health and AestheticsDallas, TX · US
- 70Hair TransplantHair Loss TreatmentsDermatologyTanveer FatimaRoorkee, Uttarakhand · IN
- 46
Hair TransplantHair Loss TreatmentsDenver Hair SurgeryLone Tree, CO · US - 29SMPHair SystemsDenver Chop ShopDenver, CO · US
Experts
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DermatologistDr. Tanvi Vaidya, MD, MBBS, MRCP
Thane, Maharashtra, India
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DermatologistDr. Tanveer Fatima, MD, MBBS
Roorkee, Uttarakhand, India
- 64
Hair Transplant SurgeonDr. Tanvir Hasan, MBBS, FCPS
Pattaya City, Thailand
- 47Dermatologist
Jeff Donovan, MD
Ottawa, ON, Canada
- 45
Hair Loss SpecialistJeff Donovan
Marlow, United Kingdom
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2 / 801 resultslearn Neem Oil
natural substance from Neem tree with medicinal and pesticidal properties