Gli2-Serpinh1 Drives Fibroblast State Transition During Skin Wound Healing

    July 2026 in “ npj Regenerative Medicine ”
    Rui Ma, Wang Wu, Chuqing Zhou, Zeming Li, Jiajun Tan, Jingwei Jiang, Yiping Zhao, Mengyue Wang, Yuanli Ye, Siyi Zhou, Xudong Qiu, Fanbin Meng, Xiao Xiang, Mingxing Lei
    TLDR Gli2 and Serpinh1 are key for skin wound healing by helping fibroblasts close wounds.
    This study uncovers the Gli2-Serpinh1 regulatory axis as a crucial mechanism in fibroblast state transitions during skin wound healing. Using single-cell RNA-sequencing, spatial transcriptomics, and both in vivo and in vitro analyses in mouse and skin organoid models, researchers found that Serpinh1⁺ fibroblast subsets are essential for wound closure through processes like re-epithelialization and vascular regeneration. Gli2 acts as an upstream regulator of Serpinh1, influencing fibroblast function across different healing phases. Additionally, the study identifies three traditional Chinese medicine candidates that enhance wound healing by activating this axis, suggesting new possibilities for precision regenerative therapies.
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