The Role of Glucose Metabolism in Wound Healing: An Overview
January 2025
in “
Burns & Trauma
”
TLDR Glucose metabolism is crucial for wound healing but can delay healing in chronic wounds due to increased stress and inflammation.
Glucose metabolism is essential for wound healing, providing energy and metabolic intermediates through glycolysis and the tricarboxylic acid cycle, and producing NADPH via the pentose phosphate pathway to manage oxidative stress and immune responses. It supports cell proliferation, migration, and tissue repair across all wound healing stages. However, in chronic wounds, abnormal glucose metabolism can increase oxidative stress and inflammation, delaying healing. Understanding these processes can lead to new therapeutic strategies, highlighting glucose metabolism as a potential target for improving wound healing outcomes.
