Study of Gonadal Hormone Drugs in Blocking Filovirus Entry of Cells In Vitro

December 2015 in “ PubMed ”

Lili Wang, Qing Chen, Lina Zhou, Ying Guo

gonadal hormone drugs toremifene citrate tamoxifen citrate clomiphene citrate estradiol benzoate raloxifene hydrochloride hexestrol chlormadinone acetate quinestrol

TLDR Some gonadal hormone drugs can block filovirus entry into cells.

The study aimed to identify filovirus entry inhibitors from a library of 1,600 commercial drugs using a ZEBOV-GP/HIV pseudovirus model. It found 12 gonadal hormone drugs with inhibitory effects at a concentration of 10 μmol/L. Notably, toremifene citrate, tamoxifen citrate, and clomiphene citrate showed strong activity with IC50 values below 1 μmol/L. Additionally, these drugs, along with raloxifene hydrochloride and quinestrol, were effective against both Sudan ebola virus and Marburg virus pseudotypes. This research highlighted the potential of certain gonadal hormone drugs as inhibitors of filovirus entry in vitro.

View this study on pubmed.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Related Community Posts Join

6 / 14 results

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 2 years ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 117 upvotes 3 years ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community Does the watery ejaculate issue ever resolve?

in Finasteride/Dutasteride 93 upvotes 3 days ago

Dutasteride and finasteride can cause watery ejaculate, which may persist for some users. Zinc supplements or switching to topical treatments are suggested to alleviate this side effect.

community Takes time my friends, years in fact

in Satire 53 upvotes 2 years ago

The conversation discusses long-term hair loss treatment, with one person seeing hair darkening after 3 years using Minoxidil, Finasteride, and Dutasteride, and others sharing their shorter-term experiences with similar treatments. They emphasize that hair regrowth takes time and to not expect quick results.

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 6 months ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

community I am horny as hell due to fin.

in Finasteride/Dutasteride 225 upvotes 2 years ago

Some individuals taking finasteride for hair loss report increased libido and frequent masturbation, with no immediate hair regrowth but darker hair appearance. A dermatologist explains that finasteride may raise testosterone levels temporarily, which could lead to increased sex drive in some people.

Similar Research

5 / 1000+ results

Emerging Medication for the Treatment of Male Hypogonadism

Study of Gonadal Hormone Drugs in Blocking Filovirus Entry of Cells In Vitro

Related Community Posts Join

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

community Does the watery ejaculate issue ever resolve?

community Takes time my friends, years in fact

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

community I am horny as hell due to fin.

Similar Research

research Emerging Medication for the Treatment of Male Hypogonadism

research Macular Abnormalities Associated With 5α-Reductase Inhibitor

research Steroid Hormones of Reproduction and Sexual Development

research Improving Selective Androgen Receptor Modulator Discovery and Preclinical Evaluation

research Implications of Chronic Finasteride Use for Androgenetic Alopecia in Prostate Carcinoma