Growth Factors and Cutaneous Pathology

August 2020 in “ CRC Press eBooks ”

Lloyd E. King, Lillian B. Nanney, Ronald E. Gates

growth factors cytokines hair growth hair follicle hair cycle epidermal growth factor transforming growth factor TGFα TGFβ-1 transgenic mice skin pathology

TLDR Abnormal growth factors can cause hair and skin issues.

The document reviewed the role of growth factors and cytokines in regulating hair growth and their impact on hair follicle formation, structure, and the hair cycle. It highlighted how abnormalities in these factors could lead to abnormal hair or fur. Specifically, growth factors like epidermal growth factor and transforming growth factor (TFGα) were shown to influence regeneration rates after burn wounds. Additionally, transgenic mice overexpressing TGFβ-1 exhibited shiny, taut skin that restricted movement and breathing, demonstrating the significant effects of growth factor regulation on skin and hair pathology.

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