A Complete Guide to Human Microbiomes: Body Niches, Transmission, Development, Dysbiosis, and Restoration

The document reviewed the human microbiome's critical role in health and disease, emphasizing its development, transmission, and impact across various body niches. It highlighted how factors like delivery mode, breastfeeding, and environmental influences shaped the microbiome, affecting risks for metabolic and immune diseases. The review noted specific microbial changes associated with conditions such as alopecia, obesity, diabetes, and neuropsychiatric disorders. It discussed the appendix's role in gut health and the impact of urbanization on microbial diversity. Restoration methods like probiotics, prebiotics, synbiotics, and fecal matter transplants were explored, with an emphasis on the need for standardized research methodologies and preserving microbial diversity for therapeutic advancements.