Hair Follicle Biology and Signaling in Female Pattern Hair Loss: A Neuroendocrine Biomarker Perspective Integrated With Artificial Intelligence-Driven Precision Diagnostics

    January 2026 in “ Dermatologic Therapy
    Debraj Shome, Debalina Bose, Raji Patil, Rinky Kapoor, Esmael Ahmed, Depti Bellani, Riya Shahare
    TLDR Female pattern hair loss can signal hormone issues and should be part of health checks for personalized treatment.
    This review highlights female pattern hair loss (FPHL) as an early indicator of endocrine imbalance, linked to androgen excess, insulin resistance, and thyroid dysfunction, which contribute to hair follicle miniaturization. It evaluates the effectiveness of treatments like antiandrogens, insulin sensitizers, and lifestyle changes, emphasizing the importance of integrating FPHL assessment into endocrine evaluations. By recognizing FPHL as a biomarker, healthcare providers can implement personalized treatment strategies that combine medication with lifestyle modifications, potentially improving hair restoration and systemic health outcomes.
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