Feasibility of Measuring Hair Glucocorticoids as a Potential Biomarker for Chronic Stress in Older Adults With Intellectual Disabilities

This study evaluated the feasibility of using hair glucocorticoids as a biomarker for chronic stress in older adults with intellectual disabilities, involving 278 participants. Hair sample collection and analysis were feasible, with a moderate success rate of 32% for sample analysis. Females and individuals with moderate intellectual disabilities had higher success rates, while males and those with severe/profound disabilities faced challenges, primarily due to shorter or thinner hair. The study suggests potential for hair glucocorticoids as a stress biomarker but highlights the need for improved methods to address collection challenges, particularly in balding males and those with severe disabilities. Further research is recommended to confirm these findings in larger and more diverse groups.