Cross-Sectional Relation of Long-Term Glucocorticoids in Hair With Anthropometric Measurements and Their Possible Determinants: A Systematic Review and Meta-Analysis

November 2021 in “ Obesity Reviews ”

Eline S. van der Valk, Ozair Abawi, Mostafa Mohseni, Amir Abdelmoumen, Vincent L. Wester, Bibian van der Voorn, Anand M. Iyer, Erica L T van den Akker, Sanne E. Hoeks, Sjoerd A.A. van den Berg, Yolanda B. de Rijke, Tobias Stalder, Elisabeth F. C. van Rossum

glucocorticoids hair glucocorticoids hair cortisone hypothalamic-pituitary-adrenal axis

TLDR Higher glucocorticoids in hair are linked to increased obesity measures like waist size.

The systematic review and meta-analysis investigated the relationship between long-term glucocorticoids in hair (HairGC) and obesity measures such as BMI, waist circumference (WC), and waist-hip ratio (WHR) across all ages. Analyzing 26 studies with a total of 11,635 participants, the study found a consistent positive association between HairGC and these obesity measures, particularly highlighting the clinical relevance of the relationship between hair cortisone (HairE) and WC. The findings suggested that increased central adiposity might be linked to an altered setpoint of the hypothalamic-pituitary-adrenal axis.

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research Cross-Sectional Relation of Long-Term Glucocorticoids in Hair With Anthropometric Measurements and Their Possible Determinants: A Systematic Review and Meta-Analysis

30 citations , November 2021 in “Obesity Reviews”

Higher glucocorticoids in hair are linked to increased obesity measures like waist size.

research Exploring Reference Values for Hair Cortisol: Hair Weight Versus Hair Protein

4 citations , October 2020 in “Therapeutic drug monitoring”

Lower tacrolimus levels (4-7 ng/mL) after liver transplant may be safe and improve graft and kidney function.

research Exploring Reference Values for Hair Cortisol

5 citations , June 2020 in “Therapeutic drug monitoring”

Hair sample weight is a better measure for cortisol levels in hair than hair protein concentration.

research Not the Root of the Problem: Hair Cortisol and Cortisone Do Not Mediate the Effect of Child Maltreatment on Body Mass Index

11 citations , May 2020 in “Frontiers in psychiatry”

Child abuse is linked to higher BMI, but not because of hair cortisol or cortisone levels.

research Hair Glucocorticoid Levels in Parkinson’s Disease

16 citations , May 2020 in “Psychoneuroendocrinology”

People with Parkinson's disease have higher levels of cortisone in their hair, which may indicate chronic stress hormone dysfunction.

research Hair Cortisol Concentration in Healthy Children and Adolescents Is Related to Puberty, Age, Gender, and Body Mass Index

24 citations , January 2019 in “Hormone Research in Paediatrics”

Hair cortisol levels in children are influenced by puberty, age, gender, and body mass index.

research Childhood Urbanicity And Hair Steroid Hormone Levels In Ten-Year-Old Children

12 citations , November 2018 in “Psychoneuroendocrinology”

research Measurement of Cortisol, Dehydroepiandrosterone, and Testosterone in the Hair of Children: Preliminary Results and Promising Indications

10 citations , November 2018 in “Developmental Psychobiology”

Hair can effectively measure DHEA and testosterone levels in children.

research Hair Cortisol Analysis: An Update on Methodological Considerations and Clinical Applications

237 citations , September 2018 in “Clinical Biochemistry”

Hair cortisol analysis can help diagnose stress-related conditions but needs more refinement for widespread use.

research Hair Cortisol Concentrations in Adolescent Girls With Anorexia Nervosa Are Lower Compared to Healthy and Psychiatric Controls

22 citations , August 2016 in “European Eating Disorders Review”

Adolescent girls with anorexia nervosa have lower hair cortisol levels than healthy and psychiatric peers.

research Determinants of Hair Cortisol and Hair Cortisone Concentrations in Adults

157 citations , June 2015 in “Psychoneuroendocrinology”

Hair cortisol and cortisone levels increase with age, are higher in diabetics, vary by gender, decrease with frequent hair washing, and are lower in winter.

research Measurement of Cortisol and Testosterone in Hair of Obese and Non-Obese Human Subjects

50 citations , June 2014 in “Experimental and Clinical Endocrinology & Diabetes”

Hair hormone levels can indicate obesity-related changes and are useful for research and clinical practice.

research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol

489 citations , June 2005 in “The FASEB Journal”

Human hair follicles can produce cortisol like the body's stress response system.