Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes

    February 2016 in “ Genetic Testing and Molecular Biomarkers ”
    Şener Taşdemir, Recep Eröz, Hasan Serkan Doğan, Haktan Bağış Erdem, İ̇brahim Şahin, Murat Kara, Ragıp İsmail Engin, Hasan Türkez
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    TLDR Hair loss is significantly linked to lower levels of certain genes in hair follicles.
    The study examined the relationship between hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes in 19 males with hair loss and 14 without. Using relative quantitative real-time polymerase chain reaction, it found that expression levels of these genes were lower in normal hair follicle sites compared to sites affected by hair loss in individuals with alopecia. Additionally, there were strong correlations between the expression levels of nucleophosmin and nucleolin, nucleophosmin and UBTF, and nucleolin and UBTF in both groups. The study concluded that there is a significant association between hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes.
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