Hand-Foot and Stump Syndrome Due to Sorafenib

January 2007 in “ Journal of Clinical Oncology ”

Susan Lai, Timothy Kuzel, Mario E. Lacouture

sorafenib hand-foot and stump syndrome HFSS alopecia hair depigmentation seborrheic dermatitis-like rash eccrine sweat glands

TLDR Sorafenib may cause hand-foot and stump syndrome, requiring early detection and management.

A 47-year-old man with metastatic renal cell carcinoma developed hand-foot and stump syndrome (HFSS) after 8 weeks of treatment with sorafenib, a chemotherapeutic agent. The patient experienced tingling and developed tender, erythematous lesions on his palms, right sole, and left stump, as well as subungual splinter hemorrhages. The case suggested a possible link between sorafenib and HFSS, potentially due to the drug's concentration in eccrine sweat glands. Other adverse effects of sorafenib included seborrheic dermatitis-like rash, alopecia, and hair depigmentation. The study highlighted the need for early recognition and management of these dermatologic side effects to continue effective cancer treatment.

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Research cited in this study

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research Mucocutaneous Side Effects of Antineoplastic Chemotherapy

55 citations , November 2004 in “Expert opinion on drug safety”

Chemotherapy often causes hair loss, nail changes, and mouth issues, but these are usually manageable.

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