Study on Heparin-Functionalized Core-Shell Nanofibers as Biomaterials Capable of Supplementing Growth Factors for Wound Healing

The study explored the use of heparin functionalized core-shell type nanofabrics as a biomaterial for skin wound healing. These nanofabrics, made from PCL/gelatin, were designed to sequester both exogenous and endogenous growth factors (GFs), addressing the challenge of GF instability and the risks associated with overdosing. The research demonstrated that these nanofabrics, called Hep-PG, promoted effective and scarless tissue regeneration within 14 days by leveraging the synergistic effects of exogenous and endogenous GFs. This approach minimized reliance on exogenous GFs alone, enhancing safety and efficacy in tissue regeneration.