TLDR Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.
In the 2015 study, researchers found that herbal extracts significantly increased the proliferation of human dermal papilla cells (DPCs), which are essential for hair growth, by affecting the expression of certain proteins and enzymes. The extracts increased cell viability and proliferation at concentrations between 1.5% and 4.5%, decreased the expression of 5-alpha-reductase type 2 (5-αR2) which is linked to hair loss, and modulated proteins involved in cell cycle progression and survival, such as Cyclin D1, Cdk4, Bcl-2, and Bax. The study suggests that these herbal extracts could be a potential alternative treatment for hair loss, offering benefits similar to synthetic drugs but with possibly fewer side effects. The experiments were performed in triplicate and repeated three to four times, with statistical significance set at p<0.05.
A user plans to experiment with creating new hairfollicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.
The conversation discusses how different factors can stimulate type 1 and type 2 isoforms of 5-alphareductase, which are enzymes linked to hair loss. Specific treatments mentioned include oral Dutasteride and topical Finasteride.
A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hairfolliclecell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.
PP405, a topical LDH inhibitor, has shown to stimulate hairfollicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.
The conversation discusses a botanically derived treatment for androgenetic alopecia using ingredients like saw palmetto, green tea, and evening primrose, showing impressive results over 270 days. Concerns include the study's uncontrolled nature and potential product motivation, with suggestions to enhance absorption through derma rolling.
