Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine

The study explored a new method for hair regeneration by incorporating human vascular endothelial cells into hair follicle germs (HFGs). Researchers found that these cells, when added to a mix of human dermal papilla cells and mouse embryonic epithelial cells, localized within the dermal papilla region of the HFGs. The modified HFGs demonstrated higher levels of hair morphogenesis-related gene expression and improved hair shaft regeneration when transplanted into nude mice, compared to HFGs without endothelial cells. The hair follicles created also showed functional and morphological similarities to natural hair. The study concluded that including vascular endothelial cells in HFGs could enhance hair follicle formation and function, offering a promising approach for hair regenerative medicine. The study involved animal experiments and cell preparation methods, but did not specify the number of people involved, as it focused on cell culture and mouse transplantation.