Cross-Signaling Between Hair Follicle Stem Cells And Dermal Lymphatic Vessels: A Systematic Review

This systematic review explores the interactions between hair follicle stem cells (HFSCs) and dermal lymphatic vessels, highlighting their role in hair growth and tissue regeneration. The review includes 10 studies, mostly in murine models, and reveals that HFSCs and lymphatic vessels engage in dynamic cross-signaling throughout the hair cycle. During the anagen phase, lymphatic vessels dilate and enhance fluid drainage, while HFSCs secrete Angptl7 in the telogen phase to maintain lymphatic function. Lymphatic endothelial cells (LECs) promote HFSC growth by secreting growth signals like IGF-1 and Sostdc1, which activate Wnt signaling. Enhanced lymphangiogenesis prolongs hair growth, whereas LEC depletion leads to hair follicle regression. A human study links aging and alopecia with reduced lymphatic networks. The findings suggest that targeting HFSC-lymphatic signaling could offer new therapeutic avenues for hair loss and wound healing.