Hepatocyte Growth Factor-Modified Hair Follicle Stem Cells Ameliorate Cerebral Ischemia/Reperfusion Injury in Rats

The study demonstrates that hepatocyte growth factor (HGF)-modified hair follicle stem cells (HFSCs) significantly improve neurological outcomes in rats with cerebral ischemia/reperfusion (I/R) injury. Using 120 rats divided into various groups, the research found that HGF-modified HFSCs reduced brain infarct volume, decreased neuron apoptosis, and improved neurological function compared to unmodified HFSCs and saline treatments. The treatment also inhibited microglia activation, protected blood-brain barrier integrity, and promoted angiogenesis. These findings suggest that HGF-modified HFSCs offer a promising approach for enhancing recovery after ischemic stroke by mitigating inflammation and supporting neurological recovery.