Hidradenitis Suppurativa: Symptoms, Diagnostics, and Therapy
April 2019
in “
PubMed
”
hidradenitis suppurativa chronic skin disorder inflammatory nodules fistulas abscesses scarring intertriginous areas terminal hair apocrine glands hyperkeratosis hair follicle occlusion dilatation rupture inflammation smoking obesity topical antiseptics antibiotics systemic TNF-α antagonists surgical intervention skin disorder hair follicle inflammation antiseptics TNF-α blockers surgery
TLDR Hidradenitis suppurativa is a chronic skin condition causing painful lumps and scarring, often triggered by smoking and obesity, and requires varying treatments based on severity.
Hidradenitis suppurativa was described as a chronic skin disorder characterized by recurrent inflammatory nodules, fistulas, abscesses, and scarring, primarily in areas with terminal hair and apocrine glands. It typically manifested after puberty and persisted for many years, with a prevalence of 0.5% in the Czech Republic. The exact pathogenesis was unknown, but it was believed that hyperkeratosis of the hair follicle led to occlusion, dilatation, and rupture, causing inflammation. Smoking and obesity were identified as main triggers. Without treatment, the disease was chronic and progressive. Standard therapy varied based on severity, ranging from topical antiseptics and antibiotics for mild cases to systemic TNF-α antagonists and surgical intervention for advanced stages. Recurrences in adjacent tissues were common despite treatment.
