Analysis of Histology and Long Noncoding RNAs Involved in Rabbit Hair Follicle Density Using RNA Sequencing

    September 2020 in “ Research Square (Research Square) ”
    Haisheng Ding, Huiling Zhao, Xiaowei Zhao, Yunxia Qi, Xiaofei Wang, Dongwei Huang
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    TLDR Long noncoding RNAs help regulate hair follicle density in rabbits.
    This study investigated the molecular mechanisms regulating hair follicle density in Wan strain Angora rabbits, focusing on differences between high and low wool production groups. Histological analysis revealed higher hair follicle density in high wool production rabbits. RNA sequencing identified 50 differentially expressed long noncoding RNAs (lncRNAs) and 38 genes between the groups. Gene ontology analysis showed significant enrichment in processes related to lipid metabolism and transport, apoptosis, and amino acid synthesis. Five lncRNAs were identified as potential regulators of hair follicle density, with three validated by q-PCR. The study concluded that lncRNA profiles enhanced the understanding of molecular mechanisms influencing hair follicle density.
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