Histopathological Characterization of Inflammatory Interparietal Involvement in Frontal Fibrosing Alopecia

January 2026 in “ Frontiers in Medicine ”

Marta González Cañete, Ana Rodríguez-Villa Lario, David Vega Díez, María Dolores Vélez Velázquez, Jose Maria Ricart Vaya, Marta Bandini

frontal fibrosing alopecia fibrosing alopecia in a pattern distribution androgenetic factors lymphohistiocytic infiltrate perifollicular lamellar fibrosis

TLDR FFA and FAPD might be related or stages of the same disease.

The study investigates the histopathological differences between frontal fibrosing alopecia (FFA) and fibrosing alopecia in a pattern distribution (FAPD), noting that FFA causes more significant structural disruption. The findings suggest that FFA and FAPD may either be overlapping conditions or stages of the same disease process. The study highlights the need for further research to understand the contribution of androgenetic factors, lymphohistiocytic infiltrate, and perifollicular lamellar fibrosis in these conditions.

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Research cited in this study

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community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 1 year ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

in Research/Science 39 upvotes 1 year ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 year ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community scarring alopecia awareness in this community

in Chat 33 upvotes 3 years ago

Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground… 25m What should I do?

in Treatment 33 upvotes 1 year ago

A user on dutasteride and oral minoxidil for two years has experienced worsening hair loss and an itchy scalp. Suggestions include increasing medication doses, trying other treatments like RU58841, getting a scalp biopsy, and addressing potential inflammation through diet and topical treatments.

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