Hollow Polydopamine Nanoparticles Loading with Peptide RL-QN15: A New Pro-Regenerative Therapeutic Agent for Skin Wounds

The study explored the use of hollow polydopamine (HPDA) nanoparticles loaded with the peptide RL-QN15 (HPDAlR) as a pro-regenerative therapeutic agent for skin wounds. HPDAlR significantly enhanced wound healing in various animal models, including mice, rats, and swine, compared to RL-QN15 alone. The nanoparticles improved the peptide's pro-regenerative potency by enhancing loading and slow-release capabilities, which promoted cytokine release and accelerated healing. In mice, HPDAlR achieved a 99.24% repair rate for scald wounds, and in rats, it accelerated oral ulcer healing to 5 days. In swine, it improved the healing rate of full-thickness skin wounds to 87.52% by day 28. The study concluded that HPDAlR could be a promising therapeutic agent for skin wounds, with further exploration needed for clinical applications.