Redox-Responsive Polymer Dot Nanozymes Coordinate Exosome-Mediated Cutaneous Regeneration via Laser-Modulated Microenvironment Remodeling

This study investigates a novel regenerative approach for cutaneous wound healing using redox-responsive polymer dot nanozymes (PDNs) combined with exosomes and picosecond laser stimulation, conducted on 45 mice. The research demonstrates that PDNs can dynamically regulate the wound microenvironment by modulating reactive oxygen species (ROS) dynamics, significantly accelerating early wound closure and activating the EGF-ERK1/2-AQP3 signaling axis. The combination of exosomes, PDNs, and laser stimulation enhances angiogenic activation and improves epidermal maturation, optimizing wound healing by modulating signaling pathways and microenvironmental conditions. The study highlights the potential of PDNs as active biomaterials for tissue repair, although it acknowledges the need for further mechanistic confirmation and validation in larger models.