HPLC Profiling and In Silico Studies of Chochurus Olitoris (Jute) Leaf Fractions Against Steroid 5α-Reductase 2 (SRD5α2)
August 2024
in “
Biomedical Journal of Scientific & Technical Research
”
TLDR Jute leaves may help reduce DHT levels, potentially aiding in conditions like hair loss and prostate issues.
The study investigates the potential of Chochurus olitoris (Jute) leaf fractions in inhibiting Steroid 5α-Reductase 2 (SRD5α2), an enzyme responsible for converting testosterone to dihydrotestosterone (DHT). Overproduction of DHT is linked to conditions such as benign prostatic hyperplasia, androgenic alopecia, and prostate cancer. The research utilizes HPLC profiling and in silico studies to explore the efficacy of these leaf fractions in reducing DHT levels, suggesting a possible therapeutic role in managing conditions associated with excessive androgen receptor signaling.
