HR Gene Variants Identified in Mexican Patients With Alopecia Areata

April 2023 in “ Current Issues in Molecular Biology ”

Andrés Ortiz-Ramírez, María Cristina Hernández-Jiménez, Iliana Guardiola-Avila, Erick de Jesús de Luna-Santillana, Amanda Alejandra Oliva-Hernández, María Lourdes Altamirano-García, Karina Janett Juárez-Rendón

HR gene Alopecia Areata c.1010G > A p.(Gly337Asp) c.750G > A p.(Gln250Gln) c.3215T > A p.(Val1072Glu) AA

TLDR A specific gene variant may increase the risk of developing Alopecia Areata.

This study examined genetic variants in the HR gene among 15 Mexican patients with alopecia areata (AA) and 15 healthy donors, identifying three variants, notably c.3215T > A p.(Val1072Glu), which was found in 47% of patients and is likely damaging, suggesting it could be a risk factor for AA. The study found significant differences in genotype frequencies between patients and healthy individuals, emphasizing the role of genetic factors in AA and the importance of considering ethnic differences in genetic research. Further research with larger populations is recommended to confirm these findings.

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