TLDR Three genes, BMP4, POSTN, and WNT5A, may help treat keloids.
This study identified three hub genes—BMP4, POSTN, and WNT5A—that are closely linked to keloid fibroblast hyperplasia and may serve as potential biomarkers for inhibiting this condition. The findings suggest that these genes could be targeted in future therapeutic strategies, although further molecular and animal studies are necessary to fully understand the mechanisms involved in keloid development.
23 citations
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January 2024 in “Journal of Investigative Dermatology” Corticosteroids can reduce scarring in acne keloidalis by targeting specific cells.
56 citations
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January 2022 in “Burns & Trauma” WNT5A contributes to keloid scars by promoting cell changes through specific signaling pathways.
305 citations
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March 2018 in “International journal of molecular sciences” The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.
418 citations
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January 2018 in “Journal of Investigative Dermatology” Researchers found four distinct fibroblast types in human skin, which could help in treating wounds and fibrotic diseases.
408 citations
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January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
