Human hair regeneration using organoids and hair-on-chip technologies

Recent advancements in regenerative medicine for human hair restoration focus on organoids and hair-on-chip technologies. These methods address the complexity of hair follicles and challenges in regenerating them, particularly in conditions like scarring alopecia. Strategies include transplanting hair progenitor populations, 3D bioprinting of skin constructs with hair follicles, and developing hair-on-a-chip models. Immunomodulatory methods and human induced pluripotent stem cell-derived skin organoids are also explored. While in vitro results, such as hair formation in mice, are promising, clinical application remains challenging. The review highlights the potential of engineered in vitro platforms to model human hair growth and facilitate translational discovery in hair regenerative therapeutics.