Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model
September 2024
in “
Journal of Microbiology and Biotechnology
”
human placenta extract HPH atopic dermatitis AD TNF-α IFN-γ HaCaT cells DNCB reactive oxygen species ROS Nrf2 filaggrin IL-6 TARC nuclear factor kappa B mast cell macrophage epidermal thickness IL-4 IL-5 IL-13 RANTES IgE placenta extract tumor necrosis factor alpha interferon gamma keratinocytes interleukin-6 thymus and activation-regulated chemokine interleukin-4 interleukin-5 interleukin-13 regulated on activation, normal T cell expressed and secreted immunoglobulin E
TLDR Human placenta extract reduces inflammation and symptoms in atopic dermatitis.
This study investigates the potential of human placenta extract (HPH) in treating atopic dermatitis (AD). Using TNF-α/IFN-γ-stimulated human keratinocytes and a DNCB-induced AD mouse model, HPH was found to significantly reduce inflammation and oxidative stress markers, such as reactive oxygen species (ROS), and restore protective proteins like Nrf2 and filaggrin. HPH also decreased levels of inflammatory cytokines and chemokines, such as IL-6 and TARC, and inhibited nuclear factor kappa B phosphorylation. In the AD-like mouse model, HPH reduced symptoms by mitigating mast cell and macrophage infiltration, epidermal thickness, and downregulation of filaggrin. It also lowered serum levels of IL-4, IL-5, IL-13, TARC, RANTES, and IgE. These results suggest that HPH is an effective inhibitor of AD development and a promising therapeutic agent for AD-like skin conditions.
