Icariside II Inhibits Gastric Cancer Progression by Suppressing the Wnt/β-Catenin Signaling Pathway

May 2025 in “ Cytotechnology ”

Rongrong Dou, Xiaowei Zhu, Xinyun Liu, Jingjing Bao, Rongrong Jin, Guangyao Mao, Hong Yu, Yifei Liu

TLDR Icariside II may help treat gastric cancer by stopping tumor growth.

The study explores the impact of Icariside II on gastric cancer, revealing that it inhibits cancer cell proliferation and promotes apoptosis with minimal toxicity to normal cells. In vivo experiments with nude mice showed reduced tumor growth. The compound works by suppressing the Wnt/β-catenin signaling pathway, essential for gastric cancer tumorigenicity, suggesting its potential as a therapeutic agent.

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