KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

March 2021 in “ British Journal of Pharmacology ”

Yeong Ryu, Dong Ho Lee, Jiyong Shim, Ji-Yeon Park, You-rin Kim, Sehee Choi, Soon-Sun Bak, Young Chul Sung, Soung Hoon Lee, Kang Yell Choi

KY19382 Wnt/β-catenin signalling hair regrowth hair follicle neogenesis alkaline phosphatase ALP PCNA dermal papilla cells hair follicles alopecia Wnt signaling hair growth new hair follicles hair loss

TLDR KY19382 helps regrow hair and create new hair follicles.

The research paper discusses the effects of a novel activator, KY19382, on hair regrowth and hair follicle neogenesis. The study found that KY19382 activated Wnt/ß-catenin signalling, increased the expression of alkaline phosphatase (ALP) and the proliferation marker PCNA in dermal papilla cells, increased hair length in ex vivo-cultured mouse vibrissa and human hair follicles, and induced hair regrowth in mice. Additionally, KY19382 significantly promoted the generation of new hair follicles. The results suggest that KY19382 could be a potential therapeutic drug for alopecia treatments due to its effective hair regeneration ability via activation of the Wnt/ß-catenin signalling.

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