In Vitro and In Vivo Models for the Development of Hair Growth Materials by Regulating the β-Catenin Signaling Pathways

This study developed a model for hair growth material development by regulating the β-catenin signaling pathway. Using 100 nM tegatrabetan (TG), a β-catenin inhibitor, researchers observed decreased proliferation and increased apoptosis in human hair follicle dermal papilla cells (HFDPCs) over 72 hours. TG also induced G2/M cell cycle arrest and suppressed hair growth in C57BL/6 mice by inhibiting the expression of cyclin D1, β-catenin, keratin 14, and Ki67. These findings suggest that TG-induced inhibition of hair growth can serve as a promising model for creating new materials to enhance β-catenin-mediated hair growth.