TLDR Enhancing glycolysis in mesenchymal stromal/stem cells boosts their immune functions and therapy potential.
The study explored how the immune regulation of mesenchymal stromal/stem cells (MSCs) was influenced by cellular metabolism, including glucose, lipid, and amino acid metabolism, which in turn affected the efficacy of MSC therapy in treating inflammatory and immune diseases. Enhancing glycolysis in MSCs improved their immune functions and therapeutic potential. While inflammatory stimuli altered the lipid profile of MSCs, the direct link to their immunomodulatory properties needed further investigation. Arginine, glutamine-glutamate, and tryptophan-kynurenine metabolism also played roles in MSC immune regulation. Additionally, MSCs impacted the metabolism of immune cells, affecting their behavior. The study highlighted the need for more direct evidence and understanding of the mechanisms behind MSC metabolism and immune abilities.
70 citations
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February 2021 in “International Journal of Molecular Sciences”
Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.
205 citations
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April 2013 in “British Journal of Dermatology”
Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.
Fatty acid metabolic signaling can activate epithelial stemcells for hair regeneration. Oleic and palmitoleic acids showed the best results, but practical application on humans remains uncertain.
Adipose-derived stemcells with ATP improved hair regrowth in male and female mice with androgenetic alopecia. The most effective treatments were low dose stemcells with ATP for males and medium dose stemcells with non-liposomal ATP for females.
Adipose-derived stemcell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.
Hair loss is linked to the loss of stemcells in hair follicles, and potential treatments include gene editing and microneedling. Discussions also mention using Minoxidil, finasteride, and dermarolling to improve hair growth.
A user's father experienced hair regrowth and other health improvements after two IV exosome treatments. The user also had four rounds of exosome therapy, noting significant hair regrowth and relief from headaches, but no change in gray hair.
Hair regrowth treatments, including stemcell injections, are discussed, with skepticism about their effectiveness compared to Minoxidil and finasteride. Derma stamping is mentioned as effective when used with Minoxidil, finasteride, and dutasteride.
